Safety Alerts & Recalls

What does this mean?

For most patients, the benefits of antipsychotic medicines will outweigh the risks. Although the overall risk of a blood clots is low, the results of this study provide a good reminder that antipsychotics should be prescribed carefully, with regular follow-ups. If you have a history of blood clots and you take an antipsychotic medicine, you may wish to speak to your doctor and review your medicine's benefits and risks, including this safety information. If you take an antipsychotic medicine and have any concerns, please follow up with your doctor.

Antipsychotic Medicines May Raise Blood Clot Risk

A recent study published in the British Medical Journal supports previous research suggesting that antipsychotic medicines raise the risk of blood clots in patients taking these medicines. The increased risk was more noticeable among new users of antipsychotics and those prescribed the newer atypical antipsychotic drugs. In general, blood clots remain uncommon, and the increase in risk found in the study equates to only a few new cases of blood clots per 10,000 patients treated with antipsychotic medicines.

Antipsychotic medicines are used to treat conditions such as schizophrenia and bipolar disorder, but are sometimes used for other conditions such as preventing nausea and vomiting.

Conventional (typical) antipsychotics include benperidol (brand name Anquil, Benquil), chlorpromazine (Largactil), flupentixol (Depixol, Fluanxol), fluphenazine (Modecate), haloperidol (Dozic, Haldol), levomepromazine (Nozinan), pericyazine (Neulactil), perphenazine (Fentazin), perphenazine with Amitriptyline (Triptaphen), pimozide (Orap), pipothiazine (Piportil Depot), prochlorperazine (Buccastem, Stemetil), promazine, sulpiride (Dolmatil, Sulpitil, Sulpor), trifluoperazine (Stelazine), and zuclopenthixol (Clopixol)

Atypical antipsychotic medicines include amisulpride (brand name Solian), aripiprazole (Abilify), clozapine (Clozaril, Denzapine), olanzapine (Zyprexa), paliperidone (Invega), quetiapine (Seroquel), risperidone (Risperdal, Risperdal Consta), sertindole (Serdolect) and zotepine (Zoleptil).

For more information, please visit: www.bmj.com/content/341/bmj.c4245.full

Source: MediGuard CRT
Publication Date: 2010-09-23
Last Updated: 2010-09-23
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