Safety Alerts & Recalls
What does this mean?
If you are using Plavix, you should consult with your healthcare provider if you are currently taking or considering taking an omeprazole product, including the brand name products Prilosec, Prilosec OTC, Zegerid, and Zegerid OTC. If you need a heartburn or reflux medicine, your doctor, pharmacist, or other healthcare professional can recommend a product that does not interact with Plavix. Since both Plavix and omeprazole can provide significant benefits to patients, you should speak to your healthcare professional before starting or stopping any medication.
Since there are several other drugs that may interact with Plavix, this is also a reminder to ask your doctor or other healthcare professional to review your complete medication list, including over-the-counter products, in order to identify and manage any potential drug interactions.
FDA Issues Reminder to Avoid Concomitant Use of Plavix (Clopidogrel) and Omeprazole (Prilosec, Prilosec OTC, Zegerid, Zegerid OTC)
The U.S. Food and Drug Administration (FDA) is reminding the public that it continues to warn against the combined use of Plavix (clopidogrel) and omeprazole because taking these two medicines together can reduce the anti-blood clotting effect of Plavix. Patients who use Plavix to prevent blood clots and reduce the risk for heart attacks or strokes will not get the full benefit of this medicine if they are also taking omeprazole. Separating the dose of Plavix and omeprazole in time will not reduce this drug interaction. Omeprazole is found in prescription products (Prilosec, Zegerid, and generic products) and over-the-counter products (Prilosec OTC, Zegerid OTC, and generic products).
The information about this drug interaction was added to the drug label of Plavix in November 2009, and continues to be discussed in the medical literature and media.
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